The B- to Z-DNA equilibrium in vivo is perturbed by biological processes.
- 1 October 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (19) , 7069-7073
- https://doi.org/10.1073/pnas.85.19.7069
Abstract
Right-handed B and left-handed Z conformations coexist in equilibrium in portions of plasmids in Escherichia coli. The equilibria are influenced by the length of the sequences that undergo the structural transitions and are perturbed by biological processes. The composite results of three types of determinations indicate a supercoil density of -0.025 in vivo. The coexistence of alternative DNA conformations in living cells implies that potential of these structures or their transitions for important functions in genetic regulatory processes.This publication has 26 references indexed in Scilit:
- Methylation of cytosine in the 5-position alters the structural and energetic properties of the supercoil-induced Z-helix and B-Z junctionsBiochemistry, 1988
- Left-Handed DNA in VivoScience, 1987
- Use of site-specific recombination as a probe of DNA structure and metabolism in vivoJournal of Molecular Biology, 1987
- Bacterial chromatin: A new twist to an old storyNature, 1986
- Hhalmethylase and restriction endonuclease as probes for B to Z DNA conformational changes in d(GCGC) sequencesNucleic Acids Research, 1984
- THE CHEMISTRY AND BIOLOGY OF LEFT-HANDED Z-DNAAnnual Review of Biochemistry, 1984
- The IN-VIVO Occurrence of Z DNAJournal of Biomolecular Structure and Dynamics, 1983
- Facile transition of poly[d(TG)·d(CA)] into a left-handed helix in physiological conditionsNature, 1983
- The facile generation of covalently closed, circular DNAs with defined negative superhelical densitiesAnalytical Biochemistry, 1982
- DNA Structure and Gene RegulationProgress in Nucleic Acid Research and Molecular Biology, 1980