ON STRUCTURAL AND FUNCTIONAL RELATIONS BETWEEN ANTIBODIES AND PROTEINS OF THE GAMMA-SYSTEM
Open Access
- 1 June 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (6) , 1035-1042
- https://doi.org/10.1073/pnas.48.6.1035
Abstract
A hypothetical scheme relating the various classes of gamma-globulins through their structural and functional properties is proposed. The evidence upon which this scheme is based is considered, and the relevance of this scheme to certain notions concerning antibody and immunologic specificity is discussed. The central feature of the scheme is the assignment of the different biological functions of antibodies to 2 different kinds of polypeptide chains of which the gamma-globulin molecule is composed.Keywords
This publication has 15 references indexed in Scilit:
- ENZYMATICALLY PRODUCED SUBUNITS OF PROTEINS FORMED BY PLASMA CELLS IN MICEThe Journal of Experimental Medicine, 1962
- STRUCTURAL DIFFERENCES AMONG ANTIBODIES OF DIFFERENT SPECIFICITIESProceedings of the National Academy of Sciences, 1961
- THE SOLUBILIZATION OF MICROSOMAL ANTIBODY ACTIVITY BY THE SPECIFIC INTERACTION BETWEEN THE CRYSTALLIZABLE FRACTION OF γ-GLOBULIN AND LYMPH-NODE MICROSOMESProceedings of the National Academy of Sciences, 1961
- STUDIES ON STRUCTURAL UNITS OF THE γ-GLOBULINSThe Journal of Experimental Medicine, 1961
- Separation of Univalent Fragments of Rabbit Antibody by Reduction of a Single, Labile Disulphide BondNature, 1961
- ALLOTYPY OF RABBIT SERUM PROTEINSThe Journal of Experimental Medicine, 1960
- THE MOLECULAR BASIS OF ANTIBODY FORMATIONProceedings of the National Academy of Sciences, 1960
- Ultracentrifugal examination of digestion products from rabbit gamma-globulin.1959
- The hydrolysis of rabbit γ-globulin and antibodies with crystalline papainBiochemical Journal, 1959
- Genes and AntibodiesScience, 1959