Regulation of Cytochrome P450 by Posttranslational Modification
- 1 January 2005
- journal article
- review article
- Published by Taylor & Francis in Drug Metabolism Reviews
- Vol. 37 (2) , 379-404
- https://doi.org/10.1081/dmr-46136
Abstract
Cytochrome P450s are a family of enzymes represented in all kingdoms with expression in many species. Over 3,000 enzymes have been identified in nature. Humans express 57 putatively functional enzymes with a variety of critical physiological roles. They are involved in the metabolic oxidation, peroxidation, and reduction of many endogenous and exogenous compounds including xenobiotics, steroids, bile acids, fatty acids, eicosanoids, environmental pollutants, and carcinogens [Nelson, D. R., Kamataki, T., Waxman, D. J.,17 Guengerich, F. P., Estabrook, R. W., Feyereisen, R., Gonzalez, F. J., Coon, M. J.,18 Gunsalus, I. C., Gotoh, O. (1993) The P450 superfamily: update on new sequences, gene 19 mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell 20 Biol. 12(1):1- 51.]. The development of numerous diseases and disorders including cancer and cardiovascular and endocrine dysfunction has been linked to P450s.Several levels of regulation, including transcription, translation, and...Keywords
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