Clonidine in prophylaxis of migraine

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Abstract
Various drugs are used in migraine to decrease the frequency of attacks. Clonidine hydrochloride, an antihypertensive agent, was reported to be effective. The mechanism of action of the drug is not clear, but it may act by affecting tyramine metabolism. A double-blind cross-over trial using clonidine and identical-looking placebo tablets was performed in 20 migraine patients. There was no statistically significant difference between clonidine and the placebo in reducing the frequency of attacks, as evaluated by the non-parametric Wilcoxon test. No side effects of clonidine were seen.