Use of the Statins in Patients After Acute Myocardial Infarction

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Abstract
THE SCANDINAVIAN Simvastatin Survival Study (4S),1 published in 1994, was the first large, randomized, clinical trial to demonstrate that lipid lowering with simvastatin resulted in a clear and substantial decrease in total mortality and in fewer coronary heart disease events and less cardiovascular mortality when used in patients with coronary heart disease (history of angina or myocardial infarction) who also had high low-density lipoprotein cholesterol levels. Subsequent trials2,3 have reaffirmed these initial findings.