Inhibition of muscular amino acid release by lipid infusion in man

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Abstract
Amino acid balances of healthy postabsorptive volunteers were investigated with the forearm technique under the influence of an intravenous infusion of triglyceride emulsions (MCT; LCT/MCT). A decrease of the basal muscular release of most of the amino acids, resulted in an increase of pre-existant uptake rates. In parallel, arterial concentrations of these amino acids declined. With constant insulin levels and substantially unchanged blood glucose levels, this inhibition of muscular proteolysis and/or stimulation of proteosynthesis is most probably die to the increased level of free fatty acids.