Enantioselective Transesterifications Using Immobilized, Recombinant Candida antarctica Lipase B: Resolution of 2-Iodo-2-cycloalken-1-ols
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (10) , 813-816
- https://doi.org/10.1055/s-1992-21502
Abstract
Five- to seven-membered 2-iodo-2-cycloalken-1-ols were resolved by enantioselective transesterifications with isopropenyl acetate in hexane catalyzed by Candida antarctica B lipase; product (R)-acetates and recovered (S)-alcohols has ee's >95%. Related studies involving 2-bromo-2-cyclohexen-1-ol, hydrolyses of 2-halo-2-cycloalkenyl acetates and use of Pseudomonas cepacia lipase are described.Keywords
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