Clofibrate in Type II Hyperlipoproteinemia

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Abstract
As part of a double-blind randomized study, the safety and the lipid- and uric acid-lowering effect of clofibrate were evaluated in 28 patients with type II hyperlipoproteinemia (HLP). A highly significant reduction of serum cholesterol occurred in type IIa and of serum triglyceride and cholesterol in type IIb HLP throughout the 60-wk observation period (P < 0.01). Of the patients with types IIa and IIb HLP, 65% had at least a 25% reduction of serum cholesterol. Uric acid was significantly reduced only during the 1st period of treatment (P < 0.05). In the laboratory measurements concerning safety, a persistent, slight reduction was observed in Hb, hematocrit and alkaline phosphatase. No significant clinical side-effects were noted. Clofibrate is considered effective as a lipid-lowering agent in many cases of type II HLP.

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