Comparative Human Cellular Radiosensitivity: III. γ-radiation Survival of Cultured Skin Fibroblasts and Resting T-lymphocytes from the Peripheral Blood of the Same Individual

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Abstract
Skin and blood samples were obtained from 34 donors, for whom there was no indication of abnormal radiosensitivity. From these, in 33 cases both fibroblast and T-lymphocyte cultures were obtained and in 26 cases at least three fibroblast and at least two G0 (resting) T-lymphocyte survival assays were possible. Within this set of results, differences in radiosensitivity between donors were significant for fibroblasts but not T-lymphocytes, although the range of radiosensitivity was similar for the two cell types (D¯ 0·90–1·68 Gy for fibroblasts; 1·26–2·15 Gy for T-lymphocytes). Furthermore, there was little evidence for a correlation in radiosensitivity between the two cell types. These results suggest limitations in the predictive value of conventional measurement of cell survival.

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