Immunologic Abnormalities in Humans Exposed to Chlorpyrifos: Preliminary Observations
- 1 April 1993
- journal article
- research article
- Published by Taylor & Francis in Archives of environmental health
- Vol. 48 (2) , 89-93
- https://doi.org/10.1080/00039896.1993.9938400
Abstract
Twelve individuals who were exposed to chlorpyrifos were studied 1–4.5 y following exposure to determine changes in the peripheral immune system. The subjects were found to have a high rate of atopy and antibiotic sensitivities, elevated CD26 cells (p < .01), and a higher rate of autoimmunity, compared with two control groups. Autoantibodies were directed toward smooth muscle, parietal cell, brush border, thyroid gland, myelin, and ANA. Chlorpyrifos exposure was implicated in the immunologic abnormalities reported. The immunologic changes were similar to those reported for other pesticides.Keywords
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