EFFECT OF VAGOTOMY AND OF SYMPATHECTOMY ON THE SENSITIVITY OF INTESTINAL SMOOTH MUSCLE TO ADRENALIN

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Abstract
The effect of vagotomy and of sympathectomy at various levels on the sensitivity of intestinal smooth muscle to the inhibitory action of adrenalin was detd. by the use of Thiry fistulae of the jejunum in unanesthetized dogs. Motility was recorded by the balloon-mercury-manometer method. The expts. demonstrated that destruction of the sympathetic or parasympathetic connections between the pre-aortic ganglia and the central nervous system resulted in only a mild degree of sensitization of the intestinal smooth muscle to the inhibitory action of adrenalin; but destruction of the connections between the pre-aortic ganglia and the intestine, whether these ganglia were previously decentralized or not, caused a 3-7-fold increase in the sensitivity of the intestine to adrenalin.

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