Methyl chloroform intoxication. Diagnosis and treatment

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Abstract
Methyl chloroform (1, 1, 1-trichloroethane) is a widely used solvent in the United States. Excessive absorption of this substance through the lungs or gastrointestinal tract produces central nervous system (CNS) depression proportional to the amount absorbed. Mild liver and kidney dysfunction may occur transiently following recovery from CNS depression. The diagnosis of exposure is established by specifically identifying the solvent in the expired breath. Serial breath analyses allow the estimation of the total amount absorbed. The treatment is supportive, to combat the effects of CNS depression. The principles of diagnosis and treatment are illustrated by four cases of accidental vapor exposure.

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