DYSKINESIA AT BEGINNING AND END OF DOSE PROVOKED BY L-DOPA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 133  (5) , 297-308
Abstract
The 4 cases [human] of dyskinesia at the beginning and end of dose caused by L-dopa presented in this series were characterized by 4 essential features: their onset at the beginning and end of the period of effectiveness of a dose of L-dopa + IDC (benserazide); their ballic and dystonic appearance associated with a reinforcement of Parkinsonian signs; the possibility of their reduction by an increase and fractionning of the daily dose of L-dopa and the particular nature of the underlying Parkinsonian problem in which they were seen, i.e., the young age at onset of the disease, the severity of akinesia and the quality of the clinical response to L-dopa. On the basis of the circumstances of their development, appearance and treatment such forms of dyskinesia at the beginning and end of dose appear to be different from classical mid-dose dyskinesia. They pose a new physiopathological problem.

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