INITIATION, PROGRESS, AND DIAGNOSIS OF DOG BLADDER CANCER INDUCED BY 4-AMINOBIPHENYL

  • 1 January 1978
    • journal article
    • research article
    • Vol. 16  (1) , 50-54
Abstract
Twenty-four beagles received 4-aminobiphenyl orally 5 days a wk for 3 yr. The dogs were examined cytoscopically at frequent intervals. Biopsy and surgery were performed according to predetermined criteria. Three basic patterns of carcinogen responses were seen. Negative or minimal disease was seen in 4 dogs. Of these, 2 remained completely free of neoplasia. Eleven dogs progressed slowly in their development of neoplasia with minor fluctuations in development. A rapidly progressive pattern was observed in the remaining 9 dogs. A large variance in the time of onset of the first positive diagnosis of neoplasia was seen. Eleven dogs underwent surgery ranging from tumor sampling to cystectomy plus ureterosigmoidostomy. Histologic types and grades and patterns of metastasis seemed to closely parallel human bladder cancer.

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