Biotransformation of Cadaverine and Potential Biogenetic Intermediates of Lupanine Biosynthesis by Plant Cell Suspension Cultures

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Abstract
Alkaloid extracts obtained from cell suspension cultures of Lupinus polyphyllus, Conium maculatum and Symphytum officinale were separated by glass capillary gas chromatography and identified by GC/MS. Cadaverine is incorporated into the quinolizidine alkaloids by L. polyphyllus cell cultures only; identified transformation products are sparteine, 17-oxosparteine, lupanine and 4 other alkaloids which probaly are α-isosparteine, α-isolupanine, 12,13 -dehy drosparteine and 12,13 -dehy dro-17-oxosparteine. Sparteine displays a biotransformation pattern in all cell cultures which is similar to the pattern after cadaverine feeding. 17-oxosparteine is converted into lupanine indicating its intermediacy in lupanine biosynthesis. A possible pathway of lupanine biosynthesis and alkaloid transformation is discussed.

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