CELL-MEDIATED-IMMUNITY IN MICE VACCINATED AGAINST MALARIA

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 34  (2) , 147-158
Abstract
Mice vaccinated with a formalin-fixed preparation of Plasmodium berghei or P. yoelii exhibited delayed type hypersensitivity (DTH) to the homologous antigen. This was manifested in increased delayed thickening of antigen-challenged pinnae of the vaccinated mice compared to non-vaccinated controls. DTH was also evident in vaccinated mice using the homing of radiolabeled bone marrow cells (BMC) to the delayed lesion as a criterion of reactivity. When P. yoelii vaccinated mice were given a live infection of P. yoelii, a marked migration of BMC into the spleen occurred, with a peak at 48 h; this was probably a systemic response of DTH. The splenic T[thymus-derived]-cells of P. yoelii-vaccinated animals transformed in vitro with a soluble extract of the homologous parasite. The potential function of cell-mediated mechanisms in immunity to malarial infections is discussed.