Treatment of the Gonococcal Arthritis-Dermatitis Syndrome

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Abstract
Patients (98) with the gonococcal arthritis-dermatitis syndrome were prospectively treated with penicillin G, at least 10 million units i.v./day, followed by ampicillin, 2.0 orally/day, to complete at least 10 days of treatment (33 patients); ampicillin, 3.5 orally plus probenecid 1.0 g, followed by ampicillin, 2.0 g/day orally for at least 7 days (29 patients); lower doses of parenteral penicillin G (20 patients); oral tetracycline (6 patients); parenteral cephalosporins (5 patients); and other regimens (5 patients). The response to treatment was equally rapid and complete in each group. At least 90% of the patients in each group had subjective improvement and defervescence within 2 days and all patients followed for at least 2 wk achieved complete clinical and bacteriologic cure. Patients with purulent synovial effusions improved significantly more slowly than patients with nonpurulent effusions or with no effusions, regardless of which treatment was used.

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