Bone Marrow Lymphocytes of the Rat as Studied by Autoradiography

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Abstract
Studies of the small lymphocyte population in the bone marrow of normal rats reveal a large population of cells which shows the same kinetics of deoxyribonuclear acid (DNA) labeling with tritiated thymidine and cell turnover as small lymphocytes in the thymus cortex. In contrast to peripheral lymphocytes, these thymus and bone marrow lymphocytes have a very rapid rate of renewal and are derived from progenitors which have a low uptake of tritiated thymidine into DNA. The findings support the view that the bone marrow contains self-sustaining, proliferating lymphoid cells which resemble those in the normal thymus cortex.