SERUM THYROGLOBULIN IN PATIENTS WITH TOXIC AND NON-TOXIC GOITRES COMPARED TO SEX- AND AGE-MATCHED CONTROL SUBJECTS

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Abstract
Patients (71) were investigated before treatment was started. Serum Tg [thyroglobulin], measured by a double antibody radioimmunoassay, was elevated in all groups with thyroid disorders, as compared to their controls, but the values showed large overlaps between groups. The highest median values were seen in the 2 groups of patients with toxic goiters (toxic adenoma and Graves'' disease). The Tg values in patients with non-toxic goiters (diffuse and nodular) and in controls showed a log normal distribution, whereas the distribution of values from patients with toxic goiters was different. No correlation was found between serum Tg and serum thyroxine, serum triiodothyronine and serum TSH [thyrotropin], respectively. Determination of serum Tg is of little diagnostic value in thyroid diseases.