Age-Dependent Changes of the Fcγ-Receptor-Mediated Functions of Human Monocytes

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Abstract
The age-dependent alterations of phagocytosis and age-dependent cell change (ADCC) activity through Fey receptors of human monocyte monolayers using anti-D human IgG-coated 51Cr-labeled human red blood cells were determined. 40 healthy aged subjects of both sexes (age: 60–85 years) and 20 healthy young people of both sexes (age: 18–25 years) were studied. The phagocytosis increased significantly with aging in both sexes, whereas a decrease in ADCC activity was found.