The Mannich Base of Troponoid and its Application. I. Synthesis of 5-Hydroxymethyl and 5-Formyltropolone Derivatives

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Abstract
Application of the Mannich reaction to 3,7-dibromotropolone gave 3,7-dibromo-5-morpholinomethyltropolone, from which 5-hydroxymethyl and 5-formyl derivatives were derived. It was found that the hydroxymethyl group of 3,7-dibromo-5-hydroxymethyltropolone can be easily displaced, and that 3,7-dibromo-5-formyltropolone has the characteristics of an ordinary aldehyde and reacts with ketones and malonic acid.

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