PHAGOCYTIC FUNCTION IN DOWN SYNDROME-I. CHEMOTAXIS

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Abstract
Defects in host defenses may provide a partial explanation for the increased incidence of infection in individuals with Down''s syndrome. Neutrophil and monocyte cellular and humoral chemotaxis were evaluated to explore phagocytic function. Fourteen individuals with Down''s syndrome and 15 matched institutionalized controls were studied. A nonmatched comparison normal group was also investigated, representing a noninstitutionalized young adult population. Neutrophil chemotaxis in institutionalized individuals (both Down''s syndrome and matched controls) was significantly impaired. Monocyte chemotaxis in this group was lower than in normals. Evaluation of humoral components of neutrophil chemotaxis revealed no significant differences between individuals with Down''s syndrome and those with no known chromosomal abnormality. Down''s syndrome subjects had diminished humoral monocyte chemotactic responses compared with institutionalized controls and normal subjects.

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