PeptidoglycanN-Acetylglucosamine Deacetylase, a Putative Virulence Factor inStreptococcus pneumoniae
Open Access
- 1 December 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (12) , 7176-7178
- https://doi.org/10.1128/iai.70.12.7176-7178.2002
Abstract
Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.Keywords
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