Histogenesis and Repair of the Hepatic Cirrhosis in Rats Produced on Low Protein Diets and Preventable with Choline

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Abstract
The hepatic cirrhosis of rats produced by Lillie, Daft and Sebrell on low-protein, choline-deficient diets is characterized by centrolobular fatty changes, followed soon by the appearance of an acid-fast sudanophilic hyaline material designated as ceroid in liver cells and interstitial, subcapsular and centrolobular phagocytes. Soon after this, trabeculae of ceroid phagocytes and fibrous tissue form. Choline treatment removes the fat from the liver cells and increases their size but leaves untouched the fibrous trabeculae and ceroid phagocytes. This cirrhosis differs from other exptl. cirrhoses and from any seen in man.

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