Borna disease virus genome transcribed and expressed in psychiatric patients
- 1 March 1995
- journal article
- Published by Springer Nature in Nature Medicine
- Vol. 1 (3) , 232-236
- https://doi.org/10.1038/nm0395-232
Abstract
Borna disease virus (BDV) is a neurotropic, negative and single-stranded enveloped RNA virus that persistently infects various domestic animal species. Infection causes disturbances in behaviour and cognitive functions, but can also lead to a fatal neurologic disease. Human infections seemed likely, since serum antibodies were detected in neuropsychiatric patients. Further proof came from our discovery that peripheral blood monocytes carry viral antigens. Here, we present the first data on different viral genomic transcripts in such patients' cells as well as sequence data of transcripts. Both viral markers seem to coincide with acute episodes of mood disorders, thus pointing to a new human virus infection possibly threatening mental health.Keywords
This publication has 20 references indexed in Scilit:
- Borna virus infections in cattle associated with fatal neurological diseaseVeterinary Record, 1994
- Phenotypic investigation of mononuclear phagocytes by flow cytometryJournal of Immunological Methods, 1994
- Genomic organization of Borna disease virus.Proceedings of the National Academy of Sciences, 1994
- Detection of Borna disease virus RNA in naturally infected animals by a nested polymerase chain reactionJournal of Virological Methods, 1994
- A novel marker for Borna disease virus infectionThe Lancet, 1994
- Borna disease virus in peripheral blood mononuclear and bone marrow cells of neonatally and chronically infected ratsJournal of Neuroimmunology, 1993
- Biology and neurobiology of Borna disease viruses (BDV), defined by antibodies, neutralizability and their pathogenic potentialPublished by Springer Nature ,1993
- Learning deficiencies in borna disease virus-infected but clinically healthy ratsBiological Psychiatry, 1989
- BORNA DISEASE VIRUS-SPECIFIC ANTIBODIES IN PATIENTS WITH HIV INFECTION AND WITH MENTAL DISORDERSThe Lancet, 1988
- Clinical and Biochemical Manifestations of DepressionNew England Journal of Medicine, 1988