Genetic Defects in Primary Hyperparathyroidism

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Abstract
Primary hyperparathyroidism is a common disorder, and its causes are uncertain. Most patients have overactivity of a single gland, in the form of an adenoma. It has been suggested that parathyroid adenoma may be an expression of parathyroid hyperplasia, because the nonadenomatous glands show subtle features of hyperplasia.1 A previous study supported the theory that parathyroid adenomas are hyperplastic in nature by suggesting that adenomas were not composed of a clone of cells.2 Arnold et al. have reexamined the matter in this issue of the Journal and have concluded that parathyroid adenomas are often, if not always, clonal.3 They used . . .