Oxygen-radical production during inflammation may be limited by oxygen concentration

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Abstract
Relationship between oxygen-radical production by rat polymorphonuclear leukocytes and O2 concentration was established by the measurement of luminol-dependent chemiluminescence at defined O2 concentrations. O2 concentration that gave 50% of the maximum stimulated oxygen-radical production was 31 .+-. 9 .mu.M for nonopsonized latex beads and 22 .+-. 9 .mu.M for chemotactic peptide. O2 concentration in rheumatoid synovial fluid was .apprx. 30 .mu.M. Radical production at an inflammatory site may be limited by O2 concentration.