Reduction of Heparin Activity by Plasma Globulins in Patients with Increased Heparin Resistance
- 1 January 1962
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 27 (3) , 157-170
- https://doi.org/10.1159/000206777
Abstract
Plasma globulins derived from patients with greatly increased heparin resistance (shortened plasma heparin thrombin time), shortened the heparin thrombin time when added to normal plasma. The effective element appeared in the fraction containing fibrinogen. The reduction in the anticoagulant activity of heparin is caused by globulins not identical with coagulation factors possessing a known anti-heparin effect, a contributing role being played by fibrinogen.Keywords
This publication has 4 references indexed in Scilit:
- Studies on Increased Heparin Resistance Measured by the Plasma Heparin Thrombin TimeThrombosis and Haemostasis, 1961
- THE EFFECT OF HEPARIN ON THE EARLY STAGES OF BLOOD COAGULATIONJournal of Clinical Pathology, 1960
- BLOOD GLOBULINS REDUCING THE ANTICOAGULANT ACTIVITY OF HEPARINCanadian Journal of Biochemistry and Physiology, 1956
- A Method for Determination of Fibrin in PlasmaScandinavian Journal of Clinical and Laboratory Investigation, 1955