EPIZOOTIC VENEZUELAN EQUINE ENCEPHALOMYELITIS IN CENTRAL AMERICA. DISEASE PATTERN AND VACCINE EVALUATION IN NICARAGUA, 1969–19701

1 March 1972

journal article
research article
Published by Oxford University Press (OUP) in American Journal of Epidemiology

Vol. 95 (3) , 247-254
https://doi.org/10.1093/oxfordjournals.aje.a121392

Abstract

During an epizootic of Venezuelan equine encephalomyelitis (VEE) in Nicaragua, 1969–1970, serologic studies on horses and cows and an evaluation of the TC-83 attenuated vaccine were initiated. Most Equidae in the Pacific littoral lacked neutralizing antibody to VEE virus. Vaccination stimulated the production of antibody detectable with the plaque neutralization test in 93% of the horses studied. As a result, it appears that the course and direction of a major epizootic were significantly altered. Cattle failed to develop neutralizing antibody suggesting that transmission of vaccine virus did not occur. VEE antigenic subtype I-B, identical to strains isolated elsewhere in Central America, was recovered from two horses.

Keywords

This publication has 0 references indexed in Scilit: