An update on: cardiovascular and respiratory changes during sleep in normal and hypertensive subjects.
Open Access
- 1 January 2000
- journal article
- editorial
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 45 (1) , 200-211
- https://doi.org/10.1016/S0008-6363(99)00329-6
Abstract
In 1969, Bristow, Honour, Pickering and Sleight [1] provided us with one of the very first descriptions of the cardiovascular and respiratory changes occurring during sleep in normal and hypertensive subjects. The study was carried out in 19 subjects, eight with normal and ten with high blood pressure, while one subject was suffering from postural hypotension. The design of the study was rather complex: all subjects had to sleep for three consecutive nights in the laboratory. On night one, systemic arterial pressure was non-invasively determined by an automatically inflated sphygmomanometer. On night two, a continuous electroencephalogram recording was performed, whereas, on night three, continuous recording of brachial intra-arterial-pressure was obtained through a small polyethylene cannula that was also used to collect arterial blood without disturbing the patient. An i.v. line was also available for injection of various compounds.Keywords
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