EARLY CELLULAR-RESPONSES IN THE PERITONEAL-CAVITY OF MICE TO ANTITUMOR IMMUNOMODULATORS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 75  (4) , 370-378
Abstract
The early cellular responses to antitumor immunomodulators and conventional inducers, especially the polymorphonuclear leukocyte (PMN) responses, were examined in the peritoneal cavitiy of mice to investigate their effect on primary defense mechanisms. Immunomodulators were classified into 5 groups in terms of PMN response on the basis of its duration (declining or persistent) and extent (high or low induction): TAK (.beta.-1,3-glucan)-type (high, persistent), lentinan-type (high, declining), yeast mannan-type (low, declining), LPS (lipopolysaccharide)-type (low, persistent), others (no effect). Since the general PMN respone is of the declining type, the persistence of PMN with TAK- and LPS-type immunomodulators is a characteristic of the PMN-inducing activity. With respect to the extent, TAK- and lentinan-type immunomodulators induced larger numbers of PMN and macrophages than conventional inducers. Some types of immunomodulators appears to affect the early host-defense mechanism. These PMN responses were compared with those to bacteria and to tumor inoculation, and the properties of substances inducing high PMN response, i.e., those with the quality of foreignness, are discussed.