Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation
Open Access
- 1 September 2002
- journal article
- review article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 93 (3) , 1159-1167
- https://doi.org/10.1152/japplphysiol.01264.2001
Abstract
This brief review presents the basic premises suggesting that insulin-like growth factor I (IGF-I), functioning in an autocrine/paracrine mode, is an important mediator of skeletal muscle adaptation. Key intracellular signaling mechanisms associated with ligation of the primary IGF-I receptor are highlighted to illustrate the mechanisms by which IGF-I may promote muscle hypertrophy. In addition, a number of recent findings are presented that highlight the potential for interactions between IGF-I-related signaling pathways and intracellular signaling mechanisms activated by cytokines or hormonal systems.Keywords
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