Intrinsic Macrolide Resistance of the Mycobacterium tuberculosis Complex Is Inducible
- 1 July 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (7) , 2560-2562
- https://doi.org/10.1128/aac.00264-06
Abstract
Mycobacterium tuberculosis is intrinsically resistant to macrolides, a characteristic associated with expression of the erm (37) gene. This intrinsic resistance was found to be inducible with clarithromycin and the ketolide HMR3004. Furthermore, underlying the phenotypic induction was an increase in erm (37) mRNA levels.Keywords
This publication has 13 references indexed in Scilit:
- Methyltransferase Erm(37) Slips on rRNA to Confer Atypical Resistance in Mycobacterium tuberculosisJournal of Biological Chemistry, 2005
- In Vitro and In Vivo Activities of Macrolide Derivatives against Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy, 2005
- Molecular basis of intrinsic macrolide resistance in clinical isolates of Mycobacterium fortuitumJournal of Antimicrobial Chemotherapy, 2005
- Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesGenome Biology, 2002
- In Vitro Activities of the Ketolides Telithromycin (HMR 3647) and HMR 3004 Compared to Those of Clarithromycin against Slowly Growing Mycobacteria at pHs 6.8 and 7.4Antimicrobial Agents and Chemotherapy, 2000
- A New Ketolide, HMR 3004, Active against Streptococci Inducibly Resistant to ErythromycinAntimicrobial Agents and Chemotherapy, 1998
- In-vitro activity of fluorinated quinolones and macrolides against drug- resistant Mycobacterium tuberculosisJournal of Antimicrobial Chemotherapy, 1997
- Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium aviumAntimicrobial Agents and Chemotherapy, 1997
- Antituberculosis activity of clarithromycinAntimicrobial Agents and Chemotherapy, 1995
- Clarithromycin is inactive against Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy, 1995