Quantitative correlation of dopamine-dependent adenylate cyclase with responses to levodopa in various mice.
- 1 March 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (3) , 1242-1244
- https://doi.org/10.1073/pnas.74.3.1242
Abstract
Mice (12 groups) with widely different neurological responses to L-dopa were obtained by selecting them from different strains and some were submitted to pretreatments. The symptoms evoked were scored by a standardized dose of L-dopa in 1 subgroup from each group. Another subgroup was tested for activation of an adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] by a standardized dose of dopamine added to homogenates of the caudate nuclei of the brains of these mice. Both sets of tests were performed randomly. When the accruing 2 sets of data were plotted against each other there emerged a straight line which fitted the data with a coefficient of correlation of 0.97 (P < 0.0001). The dopamine-dependent activity of the adenylate cyclase of the brain was shown to be a determinant of the neurological responses of intact animals to a dopaminergic drug.This publication has 11 references indexed in Scilit:
- Dopamine-Sensitive Adenylate Cyclase Occurs in a Region of Substantia Nigra Containing Dopaminergic DendritesScience, 1976
- CHARACTERIZATION OF A DOPAMINE‐SENSITIVE ADENYLATE CYCLASE IN THE RAT CAUDATE NUCLEUSJournal of Neurochemistry, 1975
- Changing the Actions of Neuroactive Drugs by Changing Brain Protein SynthesisProceedings of the National Academy of Sciences, 1974
- Antipsychotic Drugs and Dopamine-Stimulated Adenylate Cyclase Prepared from Corpus Striatum of Rat BrainProceedings of the National Academy of Sciences, 1974
- Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic DrugsProceedings of the National Academy of Sciences, 1974
- DOPAMINE IN THE MESOLIMBIC SYSTEM OF THE RAT BRAIN: ENDOGENOUS LEVELS AND THE EFFECTS OF DRUGS ON THE UPTAKE MECHANISM AND STIMULATION OF ADENYLATE CYCLASE ACTIVITYJournal of Neurochemistry, 1974
- EFFECTS OF INHIBITORS AND STIMULATORS OF PROTEIN SYNTHESIS ON THE CEREBRAL ACTIONS OF L-DOPAPublished by Elsevier ,1973
- Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”Proceedings of the National Academy of Sciences, 1972
- A Mutation Influencing the Transportation of Manganese, L-Dopa, and L-TryptophanScience, 1972
- A Protein Binding Assay for Adenosine 3′:5′-Cyclic MonophosphateProceedings of the National Academy of Sciences, 1970