Effect of sodium valproate(VPA) on cerebral amino acids: Mechanism of .GAMMA.-aminobutyric acid(GABA) elevation and possible causal relation of VPA-induced encephalopathy and glutamine level.

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Abstract
Changes of aspartate, .gamma.-aminobutyric acid (GABA), glutamate, taurine, glutamine and glycine were examined after the intraperitoneal administration of sodium valproate (VPA) to mice at a dose of 200 mg/kg. Brain levels of glutamate and aspartate were significantly reduced by VPA, while the level of GABA was significantly increased. Higher doses of VPA significantly increased the brain levels of glutamine and glycine. These changes seem to be correlated to VPA-induced encephalopathy.