Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus
Open Access
- 1 July 1994
- journal article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 14 (4) , 689-692
- https://doi.org/10.1038/jcbfm.1994.86
Abstract
The neuroprotective action of brain-derived neurotrophic factor (BDNF) was evaluated in a rat model of transient forebrain ischemia. A continuous intraventricular infusion of BDNF for 7 days starting immediately before the onset of ischemia significantly increased the number of pyramidal cells in the vulnerable CA1 sector of the hippocampus. In situ hybridization experiments suggest the neuroprotection to be mediated via trkB – receptors in the hippocampus. The data indicate a therapeutic potential for the treatment of cerebral ischemia.Keywords
This publication has 25 references indexed in Scilit:
- Cortical transynaptic activation of tyrosine kinase receptor trkB messenger RNA expression in rat hippocampusNeuroscience, 1992
- Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.Proceedings of the National Academy of Sciences, 1992
- Chronic infusion of nerve growth factor does not rescue pyramidal cells after transient forebrain ischemia in the ratNeuroscience Letters, 1992
- Failure of basic fibroblast growth factor to prevent postischemic neuronal damage in the ratEuropean Journal of Pharmacology, 1991
- BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigraNature, 1991
- Failure of the lipid peroxidation inhibitor U74006F to improve neurological outcome after transient forebrain ischemia in the ratBrain Research, 1990
- Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culturePublished by Elsevier ,1990
- Glutamate neurotoxicity and diseases of the nervous systemNeuron, 1988
- Brain-derived neurotrophic factor prevents neuronal death in vivoNature, 1988
- Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cellsJournal of Neuroscience, 1986