Localization of TGF-β and Its Receptors in the Kidney
- 23 February 1998
- journal article
- Published by S. Karger AG in Mineral and Electrolyte Metabolism
- Vol. 24 (2-3) , 149-153
- https://doi.org/10.1159/000057363
Abstract
This paper reviews the expression and localization of proteins of the TGF-β system in the kidney, i.e. TGF-β isoforms, latent TGF-β binding protein, and receptors. There is heterogeneity of TGF-β isoforms, binding proteins and receptors. TGF-βs are more evenly distributed among different segments of the nephron than TGF-β receptors, and are expressed by almost all cell types in the kidney. The spatial distribution of TGF-β and its signaling receptor may help to better understand the biologic function of TGF-β in the kidney.Keywords
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