Epidemiology of Selected Sarcomas in Children 2

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Abstract
To complement a previous survey of childhood rhabdomyosarcoma, we studied 399 death certificates of U.S. children who died in 1960–68 of others arc om as which occur primarily in soft tissue, and 297 hospital records from 15 institutions. Mortality was highest at ages 0–4 years and 15-19 years and was attributed mainly to fibrosarcoma and neurofibrosarcoma. The tumors primarily arose in the head and neck in younger children but predominated in the lower extremities in adolescents. This shift may be related to the accelerated rate of soft-tissue growth in limbs at the onset of puberty. Fibrosarcoma was the most common tumor at major sites, although liposarcoma predominated in the retroperitoneum and mediastinum and leiomyosarcoma in the gastrointestinal tract. Genetic determinants were suggested by 2 familial occurrences of sarcoma, an excess of brain and perhaps breast neoplasms in family members, and the relationship of certain cases to multiple neurofibromatosis (von Recklinghausen's disease).

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