Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons.
- 1 September 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (9) , 5895-5898
- https://doi.org/10.1073/pnas.78.9.5895
Abstract
Nerve growth factor is retrogradely transported in sympathetic and sensory neurons throughout life. Although this transport is biologically significant in sympathetic neurons, such a function was unknown in sensory ganglia. The neuropeptide substance P was used as a biochemical marker to show that sensory ganglia from newborn and adult rats respond to nerve growth factor and that its retrograde axonal transport is biologically relevant, as indicated by an increase in substance P and in general protein content.This publication has 35 references indexed in Scilit:
- Nerve growth factors in the rat irisNature, 1980
- Peptidergic neuronesNature, 1980
- Cycloheximide-sensitive synthesis of substance P by isolated dorsal root gangliaNature, 1980
- Trophic Interactions in Neurogenesis: A Personal Historical AccountAnnual Review of Neuroscience, 1980
- Substance P: Release on trigeminal nerve stimulation, effects in the eyeActa Physiologica Scandinavica, 1979
- Quantitative in vitro studies on the nerve growth factor (NGF) requirement of neuronsDevelopmental Biology, 1977
- Properties of the beta-nerve growth factor receptor in development.The Journal of cell biology, 1975
- Time course of the development of enzymes involved in the synthesis of norepinephrine in the superior cervical ganglion of the rat from birth to adult lifeBrain Research, 1972
- Tissue culture assay of Nerve Growth Factor and of the specific antiserumExperimental Cell Research, 1970
- Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific ActivityNature, 1962