Asynchronous globin chain synthesis in rabbit reticulocyte lystates induced by hemin-controlled repressor

Open Access
Publisher Website
Google Scholar
Abstract
To define further the role of hemin-controlled repressor (HCR) in globin synthesis, we studied its effect on the synthesis of individual globin chains in a rabbit reticulocyte lysate cell-free system. In the presence of HCR there was a marked globin chain imbalance, resulting in a lowered alpha/beta ratio. These findings in vitro may have relevance to certain clinical heme deficiency states in which a similar globin chain imbalance has been observed.

This publication has 0 references indexed in Scilit: