Chronological Parameters, Twin Studies, and Mental Diseases

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Abstract
Summary Genetics deals with ordered and directed biological change in time; psychiatry with the development or the breakdown over the human life span of thought, feeling, and social adaptation. With the growing acknowl-edgement of the contribution of the genotype to mental and emotional uniqueness, it is appropriate to con-sider chronological parameters of mental disease in a genetic framework. These parameters include age of onset of illness (in turn affecting clinical characteristics), sequence of morbid signs and symptoms, length of illness, periodicity of illness, and temporal relation of clinical episodes to other biological events. Data are reviewed from twin and family studies, retrospective and ongoing, that relate such time phenomena to genetic factors in psychiatric disorder. Among the conditions to be considered are schizophrenia, manic-depressive psychosis, Huntington's chorea, karyotype abnormalities, presenile and senile disease, and the psychobiological ageing process itself.

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