Cyclic AMP in the sublingual glands of the mouse.

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Abstract
The cyclic[c]AMP level in the sublingual glands of the mouse was determined in relation to mucin secretion under the influence of several agonists in vivo and in vitro. Isoprenaline increased the cAMP level in these glands only in the presence of a phosphodiesterase inhibitor, indicating the presence of an active cAMP phosphodiesterase. Inhibition of phosphodiesterase increased cAMP levels. EGTA [ethyleneglycol bis(.beta.-aminoethylether)-N,N''-tetraacetic acid] prolonged the effect of the PDE-inhibitors, indicating that Ca2+ may be involved in the maintenance of the cAMP concentration in the sublingual glands. NaF induces both a slight increase of the cAMP level and a significant mucin secretion by the sublingual glands. Other secretagogs do not significantly influence the cAMP concentration in these glands, and compounds which do elevate its level, do not significantly stimulate sublingual mucin secretion. There is probably no direct relationship between cAMP and sublingual mucin secretion.

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