Three hundred cases of recurrent endometrial cancer were treated initially by irradiation (230 cases), surgery (20 cases), combined irradiation and surgery (20 cases), and hormonal therapy or chemotherapy (30 cases) and the results are reported. Full pelvic irradiation was superior to local vaginal irradiation in lower vaginal metastases. No such differences were found in those with solitary upper vaginal recurrences where intracavitary radium was equally successful. Combined irradiation and surgery resulted in the best survival of cases with corporeal and cervical stump recurrences. In advanced cases, hormonal treatment yielded a 2 year remission rate of 25 per cent, especially in the carcinoma group of recurrences.