Multiple Genes for the Last Step of Proline Biosynthesis in Bacillus subtilis
- 15 July 2001
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 183 (14) , 4389-92
- https://doi.org/10.1128/jb.183.14.4389-4392.2001
Abstract
The complete Bacillus subtilis genome contains four genes ( proG, proH, proI, and comER ) with the potential to encode Δ 1 -pyrroline-5-carboxylate reductase, a proline biosynthetic enzyme. Simultaneous defects in three of these genes ( proG, proH, and proI ) were required to confer proline auxotrophy, indicating that the products of these genes are mostly interchangeable with respect to the last step in proline biosynthesis.Keywords
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