Specific Binding of Prolactin by the Prostate Gland of the Rat and Man

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Abstract
Specific binding sites for 125I-prolactin [PRL] are present in membrane particles obtained from the rat ventral prostate, human benign prostatic hyperplasia and prostatic adenocarcinoma. In the ventral prostate glands of young rats (1-4 mo. old) specific binding of 125I-PRL is higher than in older animals (> 8 mo. old). Subcellular distribution studies revealed that specific 125I-PRL binding activity is associated primarily with the 15,000 and 100,000 g particulate membrane fractions of the rat ventral prostate and human prostate glands. In rats between 2-4 mo. old significant increases in the PRL binding activity in the 100,000 g membrane fraction of the ventral prostate occur without concomitant increases in PRL binding activity in the 15,000 g fraction. The level of specific 125I-PRL binding activity present in the human prostate gland is lower than that observed in the rat ventral prostate gland. Localization of specific PRL binding sites in the rat ventral prostate and the human prostate gland suggests that PRL could influence the function of these tissues directly.

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