Response of Mice to Standard Infecting Doses of Mycobacterium tuberculosis var. hominis

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Abstract
Over a 5 year period 1950 through 1954, one to 6 groups per month of 10 to 30 mice each were infected intravenously with a 1 mg inoculum of the H37Rv strain of M. tuberculosis var. hominis. The median survival times of 177 (98.3%) of the 180 groups infected during this period fell between the 10th and 16th day inclusive. Statistical analyses revealed that there was no significant difference between the yearly means of the median survival times nor was there significant difference between the monthly means of the median survival times.