Cortical GABA Turnover During Bicuculline Seizures in Rats

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Abstract
The rate of cortical γ-aminobutyric acid (GABA) turnover was estimated by determining the rate of GABA accumulation following inhibition of GABA transaminase by γ-vinyl-GABA (1.5 g/kg, i.v.) in paralysed, ventilated rats. During 1 h of bucuculline-induced seizures (1.2 mg/kg, i.v.) the rate of accumulation of cortical GABA level is approximately threefold greater than in the control group receiving γ-vinyl-GABA alone, suggesting that the GABA shunt activity increases in parallel with the increase in overall cortical metabolic rate observed during bicuculline seizures. Pretreatment with γ-vinyl-GABA did not affect the bicuculline-induced changes in other major cortical amino acids.