BIOCHEMICAL STUDIES OF AN UNNATURAL AND ANTITUMOR AMINO ACID: 1-AMINOCYCLOPENTANECARBOXYLIC ACID: II. EFFECTS ON CELLULAR RESPIRATION AND AMINO ACID METABOLISM
- 1 April 1962
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 40 (4) , 433-436
- https://doi.org/10.1139/o62-049
Abstract
1-Aminocyclopentanecarboxylic acid (ACPC) was studied for its effect on cellular respiration of rat tissues and for its reactivity towards decarboxylases, transaminases, and amino acid oxidases. In the tissues studied, cellular respiration was normal. The amino acid was not decarboxylated, transaminated, or oxidized. The transamination and oxidation of other amino acids remained normal even in the presence of ACPC.Using the radioactive substance, it was found that the molecule remains intact within the cells since no metabolic products could be detected.Keywords
This publication has 5 references indexed in Scilit:
- BIOCHEMICAL STUDIES OF AN UNNATURAL AND ANTITUMOR AMINO ACID: 1-AMINOCYCLOPENTANECARBOXYLIC ACID: I. TOXICITY AND TISSUE DISTRIBUTIONCanadian Journal of Biochemistry and Physiology, 1962
- Cycloaliphatic Amino Acids in Cancer ChemotherspyJournal of Medicinal Chemistry, 1961
- IMPAIRMENT OF TUMOR GROWTH BY UNNATURAL AMINO ACIDSCanadian Journal of Biochemistry and Physiology, 1959
- The tumour growth inhibitory activity of 1-amino-cyclopentane-1-carboxylic acid and related peptidesBiochemical Pharmacology, 1959
- ENZYMATIC DEGRADATION OF AMINO ACID ANTAGONISTSJournal of Biological Chemistry, 1951