Long‐Term Follow‐Up Study of 168 Patients with Immune Thrombocytopenia. Implications for Therapy

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Abstract
A total of 168 patients (90 adults, 78 children) with immune thrombocytopenia (ITP) and a median follow-up of 75 months were treated with a sequential regimen of corticosteroids (n = 125), splenectomy (n = 83) and immunosuppressives (n = 25). In 43 patients an observation period of a minimum of 1 month preceded the therapy. It is concluded that: (i) withholding therapy in the expectation of spontaneous recovery is at least in children justified in case of limited bleeding tendency; (ii) corticosteroids should be limited in adults to a maximum of 3 weeks and in children to a maximum of 6 weeks; (iii) if corticosteroids fail, splenectomy remains the therapy of choice, especially in patients aged less than or equal to 30 years, and should be performed within 6 months after diagnosis; (iv) after failure of the aforementioned forms of therapy, there is rarely a beneficial effect of treatment with azathioprine and vincristine; (v) no reaction to any form of therapy can be followed by an acceptable long-term outcome.