Effect of N ′-Methylnicotinamide on the Renal Accumulation and Reabsorption of Gentamicin in Rats
Open Access
- 1 May 1978
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 13 (5) , 893-894
- https://doi.org/10.1128/aac.13.5.893
Abstract
N ′-methylnicotinamide, a substrate of the organic base transport system, reduced renal accumulation of [ 14 C]gentamicin in rats by 15% and increased clearance by 25%, suggesting that gentamicin is not secreted by this mechanism.This publication has 7 references indexed in Scilit:
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- Regulation of plasma choline by the renal tubule: bidirectional transport of cholineAmerican Journal of Physiology-Legacy Content, 1973